منابع مشابه
Gene Disease Interaction on Orbitofrontal Gray Matter in Cocaine Addiction
Results: (1) Individuals with CUD had reductions in GMV in the orbitofrontal, dorsolateral prefrontal, and temporal cortex and the hippocampus compared with controls. (2) The orbitofrontal cortex reductions were uniquely driven by CUD with low-MAOA genotype and by lifetime cocaine use. (3) The GMV in the dorsolateral prefrontal cortex and hippocampus was driven by lifetime alcohol use beyond th...
متن کاملGlutamate systems in cocaine addiction.
All addictive drugs facilitate dopamine transmission, and determining the role of dopamine has been the predominant focus of biomedical research in addiction for 20 years. Newer data and hypotheses have begun to shift our focus to involvement of cortex and corticofugal glutamate projections. The rationale for shifting focus to glutamate ranges from evidence showing that cortical activity is alt...
متن کاملMethamphetamine Cured my Cocaine Addiction.
Cocaine dependence is an enduring problem and years of research and drug development has yet to produce an efficacious pharmacotherapy. Recent clinical research suggests that chronic treatment with amphetamine-like medications produces tolerance to cocaine's reinforcing effects and may offer a viable pharmacotherapy. Three methamphetamine-dependent participants that had been in our clinical lab...
متن کاملAddiction to Cocaine and Amphetamine
but not DA reuptake, produce neither significant reinforcement in animal models nor euphoria in humans. Laboratory of Molecular and Developmental Neuroscience Moreover, antidepressants do not produce dependence in humans even with very long-term use. In addition, Massachusetts General Hospital Harvard Medical School lesioning of DA terminals within the NAc or full pharmacological blockade of DA...
متن کاملThe Neurobiology of Cocaine Addiction
Cocaine produces its psychoactive and addictive effects primarily by acting on the brain's limbic system, a set of interconnected regions that regulate pleasure and motivation. An initial, short-term effect -- a buildup of the neurochemical dopamine -- gives rise to euphoria and a desire to take the drug again. Researchers are seeking to understand how cocaine's many longer term effects produce...
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2017
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2017.03.019